Variations around a hit molecule can be made by using different enzymes and reaction schemes...

...including further tailoring by oxidation of the heterocycles (Thz, Oxz) and decoration with prenyl groups. Using this protocol a single substrate will yield a family of modified cyclic peptides (7 in the scheme below), each with a distinct conformation and properties. Representative product chiralities are shown, but these depend on the chirality of the starting amino acids. 

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