• Unmatched Diversity (macrocyclic compounds in unexploited chemical space)
    • range of macrocycles sizes
    • can use natural/unnatural/synthetic linear substrates
    • incorporation of heterocycles (reduced and oxidised),
    • prenylation and other modifications
       
  • Cyclisation of sequences not possible using chemical synthesis
     
  • Cyclisation of 6- 12 amino acid linear sequences is possible
     
  • Cost-effective for early stage testing and hit-to-lead optimisation
     
  • Easy analogue synthesis
    • modification of linear substrate peptide
    •  variation of tailoring enzymes
    • additional chemical tailoring on specific chemical handles
       
  • Scalability
    • discovery platform generates diversity in milligram quantities
    • individual tailoring enzymes have been produced in bulk
    • further scale-up underway to produce tailoring enzymes in kilogram quantities
    • manufacture of all products possible